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Tier-1 are;
Dodge This - 8 Con 10 Per 10 Dex
Juggernaut - 10 Str 8 Con 10 Dex
They'll still have 5 implants each but Dodge This does 50-70% more damage (meaning it doesn't need as much regen in the first place) and Juggernaut does ~30% or so more damage and has equal tankiness thanks to DR 1-3.
Biotech also doesn't matter as even a lone wolf can have Faythe/Knurl to deal with it in act 1-3.
Mind you, being tier-2 isn't really bad - it's just 8-10 Con meta with glass cannons being viable (but worse).
Both Healing Factor and Synthetic Heart together make stim penalty a non-issue, which is super nice in general play - it also makes Per penalty from Zen stim obsolete. Regarding the regeneration it's another nice thing as it heightens your capabilities to out-sustain the enemy. I usually pair Healing Factor with Regen Mutation, as well as Synthetic Heart, to get best bank for buck from regen stims.
The best builds, in my opinion, for this game, are those that are able to survive attrition, and out-sustain the enemy; enter your DR heavy Juggies and your Healing Factor builds.
Style over substance. You can only properly do it if you've already cleared the game several times (meaning discovery value isn't really there) and, while it can do everything and combat, it's barely passable at combat. Shotgun Con 12 Dex 10 Int Healing Factor will fight much better than similar Mastermind.
In solo play, can you reasonably expect to clear out enemies fast enough? Granted, I haven't attempted a Juggernaut run, but Healing Factor was a blast on my melee solo guy.
The only one thing...with Faythe or Knurl its not a solo run:)
Provided you have the money of course.
Haven't tried a Dodge this run tho.
You fight solo, bringing them for biotech only. Lone Wolf doesn't ban companions completely.
Or do you just ignore their turn during battle?