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讨论规则及指引
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I think from context it's safe to say they aren't talking about a non-combat run.
The more implants you overclock, the more penalties you get. That being said: the penalty at the 4th Overclock is -1 DR Energy, but there is a +2 DR Energy Chipupgrade to be found late game for the Subdermal implant, so you can make up for it.
On the other hand: more Dex = more AP, more Initiative, more Evasion: not having enough AP might be the difference between a standard shot, and another aimed shot that debuffs the enemy. more Initiative can sometimes be the difference between acting first and being able to throw a Brainwave Disruptor and Gas grenade that debuffs three enemies to practically skipping their turn (e.g. Smiles fight in the Factory) vs being on the receiving end of a thrown Grenade before you can even act for the first time yourself.
Edit: Some tresholds for Initiative are pretty much impossible to beat (some of the Frog encounters), other are easy to beat (Turrets were nerved in EA from 100 Ini to 30 Ini; Jia's quest now no longer has the great moment of surprise it once had in EA, nor the two turrets supporting the Robot in ECLSS (where Evans gets his personal feat). And again other encouters have a pretty high treshold, and having two more Dex can really make a difference (as described above). - Unless you take pencil and paper and write down all the Initiatives in the hard encounters, it's a bit hard to remember where your treshold should be. I mean: you can always take Fast Draw (or Fast Runner in the first place; and then maybe even Charger or Quick FIngers), get Eye and Motor Cortex, overclock them, chip-upgrade them...
Edit: for example to throw a Stasis grenade at the Floater in Zone Red right away you need 70 Ini... - which might seem overkill for some other fights (- or not enough even - depending on what you are comparing), but for this fight I found it to be very close to a treshold I could either reach or miss, depending on my choice of feats and / or overclocks.