Does reporting to the police have any penalty?

[SuperNiceGuy]

Like if I report the people at the drug den to the police station, does it make all hobo at drug den ignore me forever? Like in some game, when you join a faction, then the other will become hostile or they just ignore and don't want to talk to you, something like that?

[carlospc]

I reported to the police all the shady activities I had seen. Later Bruno was mad at me and I had to do some job to make him and Anton trust me again.