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"1 symptom left, and it was a 3-bar symptom, but it turns out it only belonged to a 1-bar disease."
Are you sure only 1 disease? or 2-3 different diseases with 1-bar? Maybe bug.
2) First thing to do is following the path. If symptoms of dementia checks but nervous breakdown is impossible, it is not dementia. You can do this with risk factors too. If you think it is sepsis but there is no "dehydration" risk factor, it is impossible (because you need dehydration to get kidney stones). Another one is checking system damage. You can practice this at death campaign. If you don't know type 1 diabetes does no damage to digestive system (instead it damages circulatory, nevous and renal systems) you might skip it. But be careful doing this. Risk factors, bad treatment, lifestyles make it harder to guess.
Tip1: Don't even check fatigue, almost all diseases have fatigue as symptom.
Tip2: AI never evolves useless risk factors. Meaning is if you have symptom of bronchitis, chronic bronchitis and asthma check risk factors at systems panel near John. If there is a flower thing (allergies risk factor) it is probably asthma and AI evolved allergies so it can evolve asthma.
3) Yes they are risk factors. Increases damage done to a system by X%. Also sometimes lowers the cost of diseases. For example with all weight related risk factors + smoking you can get first diseases of circulatory system for free and other ones really cheap.
4) Stroke damages both circulatory and nervous systems (click on it and look bottom at death campaign). It belongs to circulatory system so damage done to nervous system by stroke called "collateral" damage. Some diseases have collateral damage, some haven't (like kidney cysts). Clicking on disease shows which systems it damages and how much damage it deals (only at death campaign)
5) I go for more severe diseases and systems collapsing first. Because usually if you diagnose severe ones you also diagnose little ones. One thing I always do, leaving muscular system to last. It is so hard and expensive to diagnose... Even treatments are expensive. I try slowing it down with strength training and etc... Or simply restart stage until muscular is not a big problem. Sorry can't really give advice about it.
6) You are right. 50% treatment will reduce damage 50%.
7) Most boring thing in game is collecting bio-points. So people want to skip this part. I don't see any advantages other than that.
8) Never to use for me: Slow hands, cheap upgrades, instant lifestyles/risk factors, bio point rush, sabotaged operations, fewer symptoms.
Some weak ones can make combos like: random diseases + random risk + head start gives you a really big head start at AI race.
My favorites: Better resources, emergency room (at some stages you get +1 bio points from bio poing upgrades. you will have +2 per resource), weak diseases, weak risk, better treatments, recovery head start (only if objective is reaching 100% recovery), slow/quick collapse, collateral damage, no prerequisites, disease boost, overweight, poor treatments, long strikes.
My advice is play both campaigns, at least their first stage. By playing death campaign you will know if a disease requires another disease or risk factor. By playing life campaign you will know which diseases are harder to diagnose/treat.