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Yes you will need boosters to complete at Lethal. Another way is to always complete your path before switching systems. This one is not about confusing the A.I but to be very aggressive very fast.
A big part is getting 4-5 points from the first spawns, spend points asap and next disease's point requirement.
10% disease damage, 30% faster collapse, bio point rush and 2 random lifestyles is what I beat it with.
I think fastest way to kill John is focusing on circulatory system. Because:
- Highest collateral damage. With stroke, pulmonary emb. and postphlebitic syn. you make 4 systems collapse instead of 1.
- Highest bonus from risk factors. Weight related risk factors are most dangerous ones. Combined with weight boost they deal lots of damage. Thanks to risk factors you will pay 5 less bio points per disease.
You will need time to get all bio points for risk factors but it is not a problem for Race stage, just did it with better resources and weight boosts. This works on Deadline too but I'm not sure about Time Bomb. (By the way devs, deadline stage says "kill in 300 days" but objective is killing in 350 days)