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Along the lines of what the first commenter said, enemies are probably dealing more damage to you than your health, but OHKO protection leaves you with 1 health instead of letting you die.
If you get hit, you can regain the lost health by hitting stuff with weapons (not skills). This is represented by the yellow draining part of your healt bar.
The other mechanic is "health gating". If you have at least X% health left (unsure of exact value, but it is as long as your health bar i solid green, if it goes low enough it starts blinking and you get a red tint on the edges of the screen) you can't be killed by a singel attack. IF something would kill you, you get set to 1 HP instead, and with a lot of yellow bar you could get back by attacking stuff.
The life drain weapon had nothing to do with what happen, more so then that you hade a increased incoming damage and as such got hit for more HP then you had.
Some links to compare simillar mechanics in other games:
http://borderlands.wikia.com/wiki/Health#Health_gating
http://bloodborne.wiki.fextralife.com/Regain