"Combo" mutation

[Nathaniel Prime]

I'm not seeing a reason to pick anything but this for my first mutation. So much more DPS! Is this skill somehow less powerful than it sounds? I don't think faster grenades or 30% more health or 3 health per kill begins to compare to that much more damage. Am I missing something?

[Fel]

It depends on the stat you are using as your main, because it goes up with the red stat and it applies to your own weapons (and only once per 0.33s, usually not a problem but for bows with pierce and such it has more limited impact).

Cooldown (grenades or other powers) can have a significant impact if you have two powers affected by it, and there are plenty of other really good mutations to unlock.

But unless you are either really good and/or in a high difficulty (3+ boss cells for example) the first pick will usually go to "Ygdar Orus Li Ox", the mutation that revives you on your first death of the run because of how potent it is (plus you can't pick it if you don't take it as your first).

Personally, I tend to go for either grenade or powers cooldown reduction (depending on my main stat/gear), or parting gift/sadism if my findings in the first level makes a good use of those.
And overall, I rarely ever pick combo even later on unless I get a good combination of gear that favours speed (swift sword and a bonus that gives the swiftness after a single kill), and in those cases I combine it with the velocity mutation, which allows you to keep the swiftness boost for most of the level, with boosted crits on every single hit, but it doesn't work on bosses so it's a situationnal build to clear the normal zones.

[Nathaniel Prime]

Thank you!

[Gem of Temporarity]

It's a matter of taste.