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considering how weak 90% of the mutations are in the game right now, it's literally a choice of picking the least crappy ones. cdr, alienation and yolo heart are about all you need to get thru 90% of the runs on 4 cell. The rest of them don't even bring enough to the table to be worth considering.
the only boss fight you need separate mutations for is the hand, and it's the last fight in the game. You simply just trade alienation for fast potions or whatever else you need if you have no potion charges left.
And do not forget that not all players are hardcore ones. A pile of topics with the difficulties of beating Incomplete One boss is proof of this. So even a small increase will be useful, not to mention the greater mutation combinations.
either you don't play the alpha, or you're oblivious to how good brutality is next patch