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I miss the days when the Prison Depths made a difference of two stats, and that meant you might end up under-powered for the final boss. Back when scroll count legitimately mattered on 5BC, and choosing to skip some would've been a preposterous idea.
Lately I had the terrible (but fun) idea of playing on custom mode at 5BC with all the gameplay modifiers enabled (from FOLLOW THE LIGHT to ADAPTATION) and a few others (Things like 99 enemy curse chests and 11 mutation limit) and curses are even deadlier than I thought so I think I won't go there while I keep playing that mode.
2BC: your choice; take if you're struggling with damage late-game or if you're stuck in 2BC
Post-2BC: take