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You can even try a full ranger party with pets as tanks. Give some of them the lore skill and put them on scroll duty when needed.
Cipher is unique and one of the best classes in PoE2 period.
Skaen priest is interesting - pretty good in PoE1 and a top tier multiclass in PoE2. If you feel like being evil.
Id highly recommend multiclassing in PoE2 (especially into weapon class hybrids. Its really the best thing they added.
PoE2 is a huge step down from the difficulty of PoE1 tho so it doesnt really matter...
If id have to pick a single class for PoE1+2 id pick cipher.
I agree about druids in the first game, but now after multiple play throughs I think a wizard is far more powerful than a Druid, at least for Poe 2. Druids don't have anything on par with minolettas missiles (the 9th level spell), meteor storm, prismatic wall, wilting wind, or the insanely op shadowflame.
Imo druids are better at crowd control now while a wizard is better at straight up damaging the most amount of people for the most damage.
And while I consider cipher one of the best classes in Poe 1, I'd put it down as one of the lower tier classes for Poe 2, except for the soul blade which is insanely op (but not because of the cipher powers, but because of the soul blade move).
Worst class imo is easily the ranger.
I too recommend multi classing, unless you wanna do caster, then you can't go wrong with a straight wizard or druid
Druid, is sounding cool now too. Maybe chanter druid by PoE 2? Hmmmm.....
Overall though id say id pick the raw damage aoe dots (the numbers on every single on of their AOE dots is basically as good as high level wizard spells - but its raw! and they use way lower spellslots) + the druids incredible healing over wizard anytime.
Like with druid you get a best in slot spell that scales super well into the lategame almost every spellrank.
L1: Touch of rot (doesnt scale well due to base pen but insane early)
L2: Moonlight / Insect swarm / Autumns decay
L3: Natures Balm / Infestation of maggots
L4: Moonwell / Wicked briars
L5: Plague of insects
L6: Garden of Life / Venombloom
L7: Natures bounty / Call to the primordials
L8: Kinda crap - free rez is okay - summon is okay
L9: Pollen patch Maelstrom Galawain
All these spells are so nutty. As good as missile salvo, arcane dampener slicken etc are - i just think druid is better.
SSS-tier: Ancestors memory - gives brilliant for 12 seconds
Best spell in the game in a party - allows for insanely broken strategies. (E.g. Kind wayfarer paladin + their flame weapon thing = infinite "small range" aoe heals + aoe burn weapon buff + great damage)
S-tier: Secret horrors: You use this on paladins and rogues to stop them from using their very very powerful active abilities (and anyone else who you want to stop from using abilities - does not work on casters! spells =/= abilities!). This is a gamechanging ability if used correctly.
Nice to have:
Eyestrike - cheap long aoe blind - if you get decent hit chance -> always worth using
Ectopsychic echo - cast this on Ishiza for optimal results 100 damage base over 10 seconds in a line with no friendly fire - only downside is it rolls against reflex - very cheap as well
Pain block - long single target robust, great single target heal, cheap, never runs out, removes weakened
Cipher has a handful of other pretty good/situationally gamechanging spells but those^ are the ones i cast the most.
Stats: Max perception, high int, dump resolve
Weapon: Essence interrupter (bow) - rolls against shock +1pen from cipher very good
You should have 2 adra ban after leaving the first island -> enchant it with "peaceful summons" or whatever its called.
Skills: Metaphysics for Essence interrupter
(Any other ranged weapon will work - melee sucks)
Lategame cipher multiclasses (any weaponclass, rogue/monk esp.) are better since the last 2 spelllevels for cipher are terrible.
However the best cipher spell - Ancestors memory - is rank 7 so you only get it very very late into the game if you multi.
Serafen just sucks because of his wild magic ability. Sometimes it does good effects, but more often than not it does something really bad for you at the worst possible time.
I've lost boss battles because serafen turned them invisible and untargetable for awhile, or gives an entire aoe of enemies the brilliant inspiration (the best inspiration in the game)
Possibly, I haven't had it happen in over a year, but I also rarely use serafen now. Wouldn't be surprised because it was pretty ridiculous
Back on topic: I'm recommending a Paladin.
Last time, I used him as a barb/cipher, which helps him generate a lot of focus and then use it on debuffs for enemies(borrowed instincts and Ring Leader are very good) and buffs for allies as needed, rather than raw damage(that, he can generate from his Barb stuff). This keeps his "accidents" to a minimum, while keeping his contribution fairly high.
Further on topic(for inspiration):
So far I have played a pure Fighter(Devoted) and a Shadowdancer(using Shattered Pillar and Trickster) for my main character. Of the 2, SD was definately the most fun(the number of attacks you can generate when you crit or enemies miss you is insane).
For my next one, I will probably go for a pure Ancient Druid and bring allies that either have pets of their own or can generate buffs to them(or both). So that would probably mean Maia(Geomancer), Tekehu(Theurge) and Pallegina(Herald), and probably Eder(because he is a nice cornerstone with high strength).
This offers various buffs and debuffs, a lot of targets to block and engage enemies, access to most damage types, as well as fairly steady early game(The Spine of Thicket Green is easy to get early).
The Paladin/Chanter was really fun to play, could ramp up some pretty impressive party wide healing.