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If you have some spare permanent (not temp) health before using one, you will end up with a little bit over 80HP.
For the most of the part this doesn’t matters too much at the end of the day so I would say to not think about it too hard. Either you have spares to use or you don’t.
Although you shouldn’t heal when you don’t need to heal. Better to leave that kit. You’ll never know if you need to come back and need it
I would recommend to heal if your near a crescendo event and do not have Pills/Adrenaline.
I always heal when I'm on Black and White screen. I don't want to waste the 60 Placebo health.
As for expert, Medkits are *extremely* rare on Expert. Most of the time you will not find a single medkit outside of safehouses, if you're lucky you might get one. As such, you should save your medkits until the absolute last possible second.