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The reason why its often recommended to start with a fresh slate when using large mod packs, is unless you have put together the mod collection yourself its quite easy to encounter various conflicts and issues due to multiple mods altering the same game aspects in different ways.
Now its not impossible to add or remove things from pre-made mod packs and collections, but it doesn't always go smoothly. And not just because of the aforementioned conflicts. A mod pack or collection might also be using tweaked config files, which could be pointing towards a mod you decide to remove or a mod you add could change those config files, either of which can result in a number of issues down the road.
Then add on top of that, an existing playthrough will have pre-existing data that gets referenced. And depending on how things got changed, it can break quests, or just flat out crash the game when the existing data gets pulled and doesn't fit into what it is now expecting.
These kind of issues can even arise when adding lone mods to existing playthroughs.
So, if you want to try and see if it works with your existing mods and playthrough, you really should make a backup beforehand that you can restore to if some kind of major issue does arise. Though, depending on if and when an issue occurs, you could be set back even more hours than what you currently have into your playthrough.