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Always good to ask if you are not sure.
Texture and mesh mods can usually be freely added and removed on an in-progress game.
The only issue you could encounter from these kind of mods would be if removing the mod resulted in the deletion of the vanilla texture/mesh - resulting in purple/blue objects or NPCs/your character (indicating that the game cannot find/apply any appropriate texture).
The only kinds of mods that are generally a bad idea to remove or even add mid-progress are typically ones that deal with gameplay mechanics, quests (both vanilla and new quests), or ones that make significant changes to the landscape/settlements (though you have a higher chance of avoiding issues if it’s an area/settlement you haven’t discovered or visited yet), NPCs, and loot/inventory lists.
Texture/mesh, weapon/armor, most creature, item, separate world space, and some NPC replacer (as long as you’re not trying to install multiple ones that change the same NPCs) mods are generally okay to add/remove at will.
If you’re thinking about adding or removing a mod mid-playthrough, always check the mod’s description/comments/bug reports to see if there’s any indication one way or another, or for special instructions regarding removal.
For the complete and definitive information regarding the topic of why mods should not be removed/disabled midplaythrough, see this:
You CANNOT Remove Mods Mid-Playthrough
https://steamcommunity.com/app/489830/discussions/0/1520386297681801135/
Link is from the following section of the PINNED TOPIC Helpful Links and References:
https://steamcommunity.com/sharedfiles/filedetails/?id=2882871440