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Also it's GDDR5, not GDDRS5, don't know where you got that. The only extra variant of GDDR5 would be GDDR5X, and iirc only select Pascal cards had that. I had a Steam friend with the same GPU as you until he upgraded to the Nvidia GeForce RTX 3060 12GB GDDR6. He had Ryzen 7 2700 instead but has same amount of RAM.
You CANNOT Remove Mods Mid-Playthrough -
http://steamcommunity.com/app/489830/discussions/0/1520386297681801135/
Also, to troubleshoot your issue, follow the below outline:
Troubleshooting Your Load Order
https://steamcommunity.com/app/489830/discussions/0/3109142236155416522/
(both links from PINNED TOPIC Helpful Links and Reference, Section 5, General Troubleshooting)
Also, please post your load order in the thread so that it can be easily referred to. To post your load order, in the top left hand corner of LOOT under Game, choose Copy Load order and paste in the reply box here.
For Vortex users, Vortex keeps a .txt version of your mod load order here:
C:\Users\[your name]\AppData\Local\Skyrim Special Edition\loadorder.txt
Find it and then copy and paste it here.