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Long answer: depends a lot on the mods you want to use. Mods that change textures or lighting are no problem since that's only visible for you. It can get a little more messy when using more drastic mods, mods that actually change things. An example of this is this one mod that changes normal bandits into bandit clans. The mod itself is nice enough but it does not work well when trying to use it with other people, especially if they don't have the mod as well.
Though that last point might make the biggest difference, if the other people have the same mods it might very well work.
I would recommend as few game changing mods as possible when using Skyrim together to keep stability high enough.