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Physical
http://www.titancalc.com/TitanCalc.asp?mastery=Thane&master1=8&master2=3&sa=21&m1=32-0-1-6-1-1-8-0-12-0-0-8-6-12-0-0-1-1-0-8-0-0-0&m2=32-6-1-8-6-8-6-0-6-0-10-8-6-6-0-6-1-0-6-6-6-0-0-0
Elemental
http://www.titancalc.com/TitanCalc.asp?mastery=Thane&master1=8&master2=3&sa=21&m1=32-0-10-6-0-8-8-0-12-0-0-0-6-12-0-0-1-1-0-8-0-0-0-0&m2=32-6-1-1-6-8-6-1-6-0-10-1-6-6-0-6-1-0-6-6-6-0-0-0
You can find all of his build guides here
https://titanquestfans.net/index.php?topic=679.0
As for dualwield vs shield unless you are taking defence as 2nd mastery (which you said you wont) dualwield is the way to get the most out of warfare
Dual wield is good if you're looking to see how high you can push your DPS, but if you're worried about being too squishy, shield will provide the extra defense. Your damage should still be fine.
Any class is technically feasible, but hybrid spellcaster/warfare is likely to be more challenging as an early character.
If you're looking for range on warfare, I really like staff champion. The wolves serve as your distraction between you and the enemy, and you can toss in briar ward if you feel the need for another layer if protection, not to mention the massive pools of health and ease of healing. Doesn't really mix with a str/dex start, though the melee version would.
HP regen is really overpowered for about the first act and the ideal route to go at first, but it tapers off eventually.
Dream will work with anything and helps slow and weaken mobs, ready for hacking. If building for melee, you don't get max damage out of the electical burn spells but you still get the slow/petrify bonuses. It works will as a mage if you go that route and pump int instead of str.
I've actually pulled out the old game manuals from the boxed CDs of my original games, TQ & Imortal Throne expansion. Hunting looks good because of the bow skills and there are many times I find that a ranged attack is critical. Earth, Storm, Nature, Spirit, & Dream all have ranged skills, but I'm leery of crippling my character because of low Int, as I normally buff up Str & Dex @ level up.
I find the cyclops easier than the centaur boss that you already beat. Not sure how much a second mastery would help against him unless you've got a bunch of spare skill points, though all of those do have useful skills at the first or second tier. Between weapon training and onslaught, I would think you have pretty decent DPS now.
You probably don't need much int unless you want to be a caster or rune.
You could equip a bow in your swap slot without worrying about your second mastery if you only want to use it for occasional use but fight melee most of the time. I like hunting. Not sure I'd try it with warfare, but if you do, you'd need to choose between bow and marksmanship or melee and onslaught/possibly dual wield. Or you could use either (mostly) with throwing weapons, which splits the distance.
I like ranged for the survivability. I have a harder time with that in melee, constantly chugging potions. One good exception I found to that is spirit with life leech/damage conversion to health, and you also get a liche to help back you up in that case.
Oddly enough, I have used nothing but green weapons with essence/embodiments added and they have performed better than any epic drops I found. Not sure it that was the case when you played the original game. I never played until the updated version of the game. Even now I have had a couple legendary axes fall but I still have a green sword that is better, because of the 50% slow on it.
Melee is so equip dependant regardless of 2nd mastery. I am playing a Dream/Spirit (not sure what that class is called - never have looked, lol) Sort of a hybrid because it currently has about 435 str and 300 int. I totally play it melee though. Using temporal rift to petrify for 4.3 seconds and then hit everything so they are slow when they start to move. I believe I posted that it would do 6 seconds of petrify but i remembered wrong, or was looking at stats from the original game instead of the updated one.
My toon is now level 52 and doing alright about 2/3rds into act 3 epic. Hasn't died yet. Close several times when I was entrapped. (no gear for that yet :P) But I have decent gear from other level 40 toons that have farmed 'Valley of Kings'
Totally off topic now.... The tigermen just at the end of the 'great wall' area tend to drop some of the best green swords in normal anyway. stuff with 30+ attack speed, elemental damage straight and % etc. Sometimes they have 6 bonus traits. Had a sword there that took me to about level 42.
When picking a 2nd mastery don't forget about the bonus attributes it gives. Dream is a tweener in that it does add str when you put points into the mastery levels. Some masteries don't.