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http://titanquest.wikia.com/wiki/Hades_-_God_of_the_Dead
If I understand correctly, and you talk about the death orb.
You basically only need that resistance late in Act 4 from the Tower of Judgement onwards for those Melinoe casters and for Hades himself. Good ways to raise it are Legendary Demon's Blood charms with 85% resistance (with completion bonus) in rings or amulets and the divine artifact Crosier of Osiris (100% vit. resist.). I always have that artifact at the ready whenever I go to Hades.