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In general, try to run as few research labs as possible. Each active research lab imposes a 10% penalty on ALL research labs; the hawking institute has a separate penalty for other hawking institutes. Wiki says the penalty stacks all the way down to 50% efficiency. There are clever strategies for how many of each building to keep, but keep them fully staffed and roughly in equal number and it'll work out fine.
Each tech you research will reveal the next one down on that particular tech tree. Anomalies reveal techs allowing you to skip over techs somewhat, but generally if you want to reveal a certain tech in a tree you need to research the already revealed techs. If none of the revealed techs are useful to you, then start with the cheapest one in whatever tech tree interests you. Eventually you'll uncover what you want or something useful.
For example, Low-G High-rise (apartments) occur in Engineering randomly (depending on map) in positions 1-5. If that's not revealed yet, start researching whatever is currently revealed in Engineering to eventually uncover apartments.