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- Loader Art (+50% clip size and +100% reload speed)
- Incendiary Bullets (set enemy on fire on crit)
- CritHeal (+2 heal on crit)
- Nano Vampires (60% chance of healing 0.5% maximum health on kill)
- SkinWeave (+50% health)
- SkillWires (+20% fire rate and +20% reload speed) or GunMechanix (+20% rate of fire)
- Deflector Field (block 5% damage for every 50 points of energy, max 40%) or Pain Collector (40% damage converted to energy) or Titanium Cranium (block 20% damage)
Add any weapon with high crit. As far as I can see, plasma assault rifle, plasma burst rifle, and plasma shotgun seem to be those with the highest crit, namely 24% at level 25. To keep large groups in check and quickly dispose of nanite swarms, I like to use the Blast Granades plus:
- myGrenade (-50% fuse time and +40% radius of grenades)
For the remaning mod, add either extra health or extra rate of fire.
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Here's the idea.
Maximising crit chance increases both damage and healing, and increasing fire rate also improves the amount of crits. The extra reload speed and clip size complensate for having to rely on plasma weapons.
At the same time, increasing your maximum health both increases your survivability and the amount of health gained per kill. At max health, with SkinWeave you get about +12 health points from Nano Vampires, not to mention more health from AutoDocs. Also, the damage reduction makes the healing all the more effective.
With this I just completed a full run of OS 6 at the first try. Note that I always do full runs, and clear each level (minus enemies behind locked doors), so your mileage may vary if you play differently.
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To make this work, buy Loader Art, CritHeal, and Nano Vampires, one of the weapons at level 10 or more, and any grenades you like. Costs about 15000 credits and requires having beaten OS level 3. If you haven't, prioritise CritHeal, then Loader Art. Look for the other modules during your run.
Until you hit OS 7.0 or higher things are easy going.