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On the other hand, destroying nests increases evolution factor rapidly(by how much, depends on your map settings). You can check the current value with "/evolution" command. Evolution can be between 0 at the start of the game, and 1.0 (asymptotically approaching this value, but never actually reaching it). There are a couple of milestones in this progression, where new biter types appear:
0.2 - first appearance of medium biters
0.25 - spitters start spawning
0.5 - big biters appear
0.9 - behemoth biters.
You can read more in the wiki: https://wiki.factorio.com/Enemies#Defense
Be sure to see everything on the map before the pollution cloud gets there and clear all nests before this cloud reaches them atleast until you have proper defenses set up
First is proximity, if you are close enough to a group, it will attack you. This includes groups that were travelling, be it to expand or to attack. It also works for turrets.
Second is damaging a spawner, the whole nest's group will attack you and the spawners will spawn new ones relatively quickly to replenish the force (this is what makes attacking a large nest tricky, on top of the worms).
Third is when pollution reaches a nest, spawners will absorb it and create an attack force that will then head towards whatever produces the most pollution nearby and try to destroy it as well as whatever is nearby.
The enemies that spawn depend on what is called "evolution", it goes up based on time, pollution produced and spawners destroyed.
The wiki page on enemies is pretty detailed, if you want more specific informations:
https://wiki.factorio.com/Enemies
Since it increases the evolution though, you typically only want to clear the nests that are close to your pollution (or already in of course) as well as the ones where you want to make mining outposts (soon to be in pollution as well anyway).
No production means no pollution, whatever pollution cloud you have remaining will quickly shrink as it is consumed by environment(trees, green tiles). Biter attacks will also seize shortly after and you will have more time to rebuild/upgrade your defenses.