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For your defenses I don't know what you use, but if you don't use themyet, add some flamethrower turrets, they are great when defending against large groups (together with the other two turrets).
Power armor mk2 with all of the relevant equipments (portable fusion reactor, personal laser defense, shield, exoskeleton) will make you both fast, durable and more powerful at short-ish range.
Nukes can deal with whole chunks of the nests at once.
Last but not least, artillery turrets can target the spawners and worms automatically from pretty far away.
It does trigger an attack from the bitters and spitters since it only damages structures but it's the most effective way to get rid of big nests in the late game.
Since it's your first playthrough, 25 hours does not give us much in terms of informations about where you are at in terms of tech, some people take that long to even set up the blue science packs, others could already be nearing launch by that point.
Sometimes it is easier to face a couple of medium to large biters and spitters than facing a horde of lil critters.
Also it needs to be mentioned if one attacks a spawner, the attacked spawner will continuously spawn new biters/spitters as long it takes damage. (In relation to an arta hit, it spawns several at once)
But beware of the worms! Poison will quickly drain your health! Thats some nasty stuff.
So far:
I guess you will be near or at tank tech and thats what you should focus on for now. Get the early power armor, add some personal laser defenses to it, equip the tank ith some flamethrower and normal ammo and just roll.
If you have better equipment, still use the tank untill you get a spidertron but gear up with better ammo, maybe a rocketlauncher and explosive rockets and better armor and equipment.
Personal defenses workfrom vehicles aswell.
The other way would be a turret creep. You approache the nests with turrets which are covered with each others range untill you can strike the nest good enough. This technique only accomplishes the task if you creep near enough the nest that the turrets can attack the spawners and support you aswell and vice versa.
Better equipment like powerarmor, better ammo and weaponary is beneficial, too.
(The third way would be a rambo charge and will likely result in death...)
You can reduce the amount of pollution that the mines are producing, and therefore reduce the frequency of the attacks, by placing efficiency modules in the miners,
If you have advanced to robotics and have construction bots, you can build a small network to autorepair any damaged walls.
Use the map overlays to make sure that every section of your defence wall is covered by at least 3 turrets,
To make sure that the turrets don't run out of ammo while you are away distracted on another part of the factory, maybe use a programmable speaker to warn you when the turrets are running low. (This tip assumes that the turrets are belt fed and the speaker is measuring the amount of ammo in a chest that is supplying the belt.)
And like somebody said higher up, research better ammo, and improved turret damage and increased rate of fire.