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You can reliably clear out biters once you have AP bullets, heavy armor, and grenades. (and preferably all the red and green research for bullet/turret damage/speed).
Some people actually build walls outside their pollution cloud, so the biters can't even expand into it. They'll never turn hostile if they're never exposed to pollution, so this method keeps you safe -- but requires a lot of building very far away from the base.
Their evolution must have changed then, because I tried that once... and the nests far out from my main factory evolved to producing much stronger Biters the second I killed off the existing Biters in them. At least in early 0.15 builds, the Biters had a natural evolution progression that caused them to evolve automatically the more resources you mined up, which made it an inevitable losing game trying to keep up with them: clearing them out made the surviving nests evolve extremely fast.
Also, the biters evolve slowly over time and when they are killed or when a nest is killed. in another words build your base quicker and don't expand into thier territory until you really need to.
It's also a good idea to kill a base as soon as they send out an attack. This stops them from sending constant biters to get murdered which will increase the evolution rate.
Also throw down a turret with some ammo on top of the base you killed. It will keep them from trying to reclaim that area.
The tank is very good at clearing out biters until the green biters start appearing.
Biters are incredibly easy to clear out once you get nuclear bombs.
The biggest problem I've seen is when they've evolved to the point where they can't be killed without things that require blue tech -- which needs oil -- and there's a big biter nest on the only available oil patches.
Factorio seems very sandboxy when you first start playing, and it isn't readily apparent to new players that they're on a time limit. Danger is looming and they need to get ready. You pretty much need to have a plan for how to deal with your nearby nests BEFORE your pollution cloud reaches them.