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You can always make a backup of your save file, but generally speaking it should be safe to just jump in and pray nothing bricked. Don't sleep and it wont save.
Updating: Smapi shows mods that can be updated in purple text. Skim through the console window for it. If you are using a mod manager, it may also tell you. Stardrop, for example, you can click the Status header to sort mods and put them all at the top (or bottom) of the list.
While this isn't strictly accurate, any mods you want to use after the 1.6 patch will need to be updated. Unlike other mod updates, this one is based on coding changes to the base game - which means the earlier versions of the mods wont work. You should be fine to run the game without mods without needing to update mods. See what I said about save files.
I can't give an answer to #3, but I doubt it
Thanks for all your other answers.
There's an exhaustive (but incomplete, but official) list of things which may break and of things which got updated.
Among other things.
Not Vortex.
Probably neither classic Nexus Mod Manager.
I didn't encountered a proper mod manager which wouldn't introduce some useless or outright harmful ♥♥♥♥♥♥♥♥ yet.
All I need is:
1. Download mods.
2. Install mods.
3. Update mods.
(4. With all relevant dependencies.)
♥♥♥♥ like mandatory reminder about paid subscription you don't need, or staging feature which TRIPLES storage space for mods with no positive impact on anything, should be optional and disabled by default.
For some reason, mod manager makers are above common sense in that regard.
Don't be discouraged from mod managers. My own experience over 2 decades is very different from what was said here. Even if it ends up not working out for you, finding 1 that does work is worth more than all of times it didn't.
now that I look at, I tried using it 2 years ago and found it very confusing. I am better off managing my mods myself, as NEXUS tells me which of my mods has an update available.