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You're not the only one and hopefully this can be patched later on. Here is what I wrote earlier in a thread on the same topic.
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"I had to load a save way back but I've finished it now. Unfortunately I think the only solution is to go back and restart (at least until they patch this)
During the save in which bugged out, I never saved the man getting questioned, who the lady executes. I also never talked to Dr Hypatia before finding out she was the Crown Killer. After doing this I can now progress as normal."
If not, perhaps someone could send you a save file in that area, otherwise you probably need to restart the game :(
I don't suppose it matters if you kill/save her. It's right after you talk to the Dr where it is bugged, once you complete this, you should then be ok.
If you go talk to the patient, that's when it all triggers.
Bomb3r is right. Just redid everything from a save near the beginning and talked to the guy who was going to be interrogated, then talked to the doctor, then vasco (her assistant). Once I exhausted all their dialogues and grabbed the captive guy's notes in the highest room of the tower, I killed her and was able to proceed.
After that, you're good to go.