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I shot her with 5 sleep darts and threw a bottle of Chloroform and she didn't blink.
I was forced to kill her.
She appears to sense me immediately when I'm in certain radius. I can try again, but I don't have high expectations.
I slowed down time, waited for Crown Killer to pass below me, teleported behind their back and took them out. No detection, no kills. Perhaps it's possible to execute this without Bend Time, but it's still helpful.
On a side note, talking to Vasco ALWAYS triggers Crown Killer cutscene for me. Also, they appear to be immune to the sleep darts - at least five of those didn't even slow them down.
Still, it's a bit annoying that I somehow got detected during attempt at drop asssasination. Maybe it was a one-time fluke...
Also, I'm quite certain it's possible to perform a "drop-inject" because I think I once did just that, though by accident. I had intended to do a non-lethal aerial takedown. :)
I cannot argue much if someone has actually successfully sleep-darted Crown Killer, but I thought it was supposed to be impossible. Also, sleep-darting or any attempt at Dr. Hypatia's life will trigger her transformation into Crown Killer.
And, it's also possible to proceed towards the non-lethal solution without talking to Vasco. You need to find him anyway to get the safe code. I think if you listen to the audiograph in the same room where he is, it will trigger Crown Killer transformation, but she will not rush into that room. Just an alternative approach to try, though you will still have to leave that room and head for Vasco's lab without being detected.
After having said that, couldn't one just sneak up to her "before" she transforms, lets say, just after talking to her, while she's muddling around? Take her down non-lethel and then go talk to Vasco?
If you are playing with no powers on a low chaos run, you still have to be sneaky and come up behind her... I used the ledge above the central area to survey the surroundings to then make my move. It worked like a charm.
In any case if you are going for the Souvenirs achievement, you have to deal with her in a non-lethal way else that syringe will not appear in your quarters