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The illnesses are perks that could increase your click damage, your crit damage, increase the timer on bossfights, the boss hp, increases duration of your skills or increase teeth gained while idle etc etc.
The equipment will give you a random illness effect that you don't have to spend sins on to get,
I've also noticed that there is different rarity of equipment, for example I have a mediocre weapon with blue color name, but my gloves are of legendary color with yellow name. It looks to me like the legendary equipment is 200% base value of a normal illness while the mediocre gear is 100% base value of an illness.
There are 3 different ways to amnesia/ascend. The first way is to spend real money in shop and get "instant ascension", which costs a pretty freaking penny if you want all 250 for achievement. The second way is to unlock the Pet/Minion named "Bug", no this is NOT the bee/wasp that randomly appears in screen. With this pet/minion you lvl it up to lvl 75 and its "amnesia" skill will unlock. As soon as you buy this skill it automatically activates and resets you back to floor 1 so be warned as that is what happens when you "amnesia". The third way is to make your way to floor 105 and beat the boss. I have noticed that after beating floor 105 a little icon appears under the shop icon that lets you ascend/amnesia.
Crystals are used to buy the shop items where as Sins are used to buy illness in the illness tab. Also Sins give you +10% dps per sin. So 10 sins gives you 100%dps. I have 18,182 sins after using amnesia(got to floor 3800 which gave me around 70k-80k after amnesia as you get more depending on how far you get before ascending/amnesia). This means from my 18,182 SINS (not crystals) I passively get +181,820% dps.
Lastly I just want to add that on ascension you restart back at floor 1 with no pets or upgrades. You do keep these following things however
1. ALL sins that you had b4 ascension and your new 1s for this ascension
2. All gear like shirts, shoes, ect.
3. All crystals and things bought with them like double dmg in the shop.
4. All pet enhancements acquired from killing higher lvl bosses. These are the ones under the "Pet Enhancements" Icon that will unlock later as you progress.
5. All achievements and achievement progress and completion bonus (like any dps bonus ect.)
6 Finally all purchased illness under the illness tab.
I recommend getting to floor 101 and beating it b4 amnesia each time if possible since you get 1 random gear (shirt, pants, ect.) per play through for that floor guaranteed.Enjoy
Thats wrong you get to Pet Bug then use it to get sins and go foward in game :)