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i mean, i am doing my best, but both Ghoul Bishop and general are not relay pleased with the result.
Either way, i don't think that loosing a couple of ghouls really affects anything other than final dialogue.
Also, Supermutants have terrible PE, so if your PC has Big guns and 8+ PE (which he should) engaging them at range.
Exception: Toccamata's fortress in St.Louis. There's highest level mutants with what looks to be 300%+ Big Guns, using Brownings with Depleted Uranium. You need several doses of Psycho (Must have high EN or you will overdose) so you have 150%+ Damage Resistance. Even then, if they roll a high crit (Very rare, as they have 4% chance) (Fallout Tactics uses different Critical roll table than FO2) it can do the bypass armor and hit for 400 damage which is instant death.
And yeah, I pretty much ignored Big Guns skills or squad members due to experiences from Fallout 1 and 2...Only got 1 with RPG, and she can't cover 2 gates at once. And I sold all SAW's I came across, and can't afford to buy them back....and don't have gambling skills to get them back.....
just be careful with mutants carrying 50 cal brownings.
Use chems and high PE Big Gun recruits like the others said
But with Voodoo-powered 100% crit chance and rolling armor bypassing criticals with Better Criticals and Kamikaze, its total damage is much better than most other big guns except Browning and Gauss Minigun. With human enemies you don't even need to roll high on the crit table, even regular crits are one-shots, or one-bursts to be more precise.
Thing is, Browning ammo is quite scarce for the majority of the game. On the other hand Vindicator is available after 1st mission if you know what you're doing and you can easily get > 10 000 ammo with it from missions and even more from random Super Mutants in random encounters.
It comes down to situation and preferance, I guess. Like a lot of things.
I always disliked miniguns for the fact that you can't fire from prone and felt it wasn't so much superior to the 249 for all the amount of ammo that it wastes.
Some things to consider Harukage (and others in the same boat)
M2: strongest damage, 6 bursts before reload. Heavy ammo, high STR req, scarce ammo overall.
Vindicator: 4 bursts before reload, common ammo, lighter load overall. A smidge less damage, lower damage per shot (consider DT and DR of enemy) can't prone.
M249: 3 Burst before reload more damage, higher per shot damage than Vindicator even more common. Less range (40 vs 45), less overall damage.
Side notes: I think the M2 has a higher innate crit chance as well (TheWorld might know something of this) not 100% sure on that.
The Vindicator animation might take a small fraction longer than the others, which in those round the corner quick draw scenarios might make a difference (Insane/ Tough Guy). Not 100% on this either. Need to get back up to the higher missions and test stuff.