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Back when I was using Bitdefender it started interfering with a game called Ostriv, letting it load an existing save but shutting the game down when I tried to start a new one. By all appearances Bitdefender wasn't the culprit and it never caused any problems with the game before. Even the developer was stumped but after trying several other fixes with no success I disabled it just to see what would happen and it suddenly started working again. I uninstalled Bitdefender and went back to MSE and never had another problem with that game.
Step-by-step solution (4 steps)
1) Permissions and antivirus: Log in with an administrator account. In your antivirus (or Windows Defender), add exclusions for the folder C:\Program Files\Denuvo Anti-Cheat\ or for the file denuvo-anti-cheat-update-service.exe. You can also try temporarily disabling the antivirus to see if the service remains enabled after a reboot.
If disabling the antivirus prevents the service from being disabled, then the issue lies with the security software.
2) Manually configure the service: Open services.msc (Windows Services) with administrator privileges. Look for Denuvo Anti-Cheat Update Service, right-click on it and select Properties. Set the Startup type to Automatic. If the service is stopped, click Start.
Alternatively, open Command Prompt (CMD) as administrator and run:
sc config "Denuvo Anti-Cheat Update Service" start= auto
sc start "Denuvo Anti-Cheat Update Service"
This forces the service to start automatically.
Then close CMD, restart your PC, and check the service status again in services.msc. If it's still enabled, continue with the next steps.
3) Scheduled task reinforcement: As an additional measure, create a task in the Windows Task Scheduler to re-enable the service at system startup. For example:
Open Task Scheduler and select Create Task.
In the General tab, check “Run with highest privileges” and set it to run under the SYSTEM account or a local administrator.
In Triggers, add a new one: At system startup.
In Actions, choose Start a program and set the program to cmd.exe with the following arguments:
/sc start "Denuvo Anti-Cheat Update Service"
4) Modify the Registry: Open the Registry Editor (regedit) as administrator and navigate to the key:
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Denuvo Anti-Cheat Update Service
In the right panel, look for the Start value (REG_DWORD). Its value defines the startup type:
2 = Automatic
3 = Manual
4 = Disabled
If it doesn’t exist or is set to something else, double-click it and set Start = 2. This sets the service to automatic startup. Close regedit and restart again to verify it's still enabled.
Close everything, reboot, have fun. Cheers