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I dont and i wont take loot blind. Even in borderlands i watch for every single white stuff if its worth for me to loot or not, and if its only worth for selling or not.
WARNING: Once you open a door, and take what is behind, the door will be locked again later. DONT OPEN IT AGAIN! Waste of lockpicks, there will be nothing else behind that door.
About the Medison Mission one, you have to have a lvl2 filter behind that door, and ususally you dont have it if its your first mission. You probably will have to redo the mission to explore that area, having lvl2 filter.
All of this is true and correct.
What is also true and correct is that you can sprint to the box, open it, and loot it before you die here, netting you a couple of nice blues on an early mission.