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The overall ending is more or less the same whether you take joy or not. But if you didn't take any joy there's an additional scene after the main ending which gives a little backstory for two characters. Though this scene is pretty much just that, extra information. The events in the scene aren’t a consequence of your actions.
However, not taking joy does change the dialogue in certain scenes earlier in the game. Namely the ones where a character will call Brad out for being a drug addict. If you haven’t taken any joy, Brad will point out he isn't taking joy anymore. It doesn’t really do much to change the other person’s opinion of Brad though.
There isn’t too much harm in doing a joyless urn first. I know my first run was a joyless run (joyless AND armless
Hopefully this helped a little.
That said, extra scene for going joyless is a pretty short one (and pretty easy to look up if you miss it and don't feel like doing another run), so if you find yourself getting stuck and frustrated without using any joy, you can just go ahead and use it.
Even if you do care about those very minor line changes, you can just see them when you do a second runthrough on Pain mode, where you don't lose out on anything by taking joy. The differences on Pain mode are also a bit more substantial, like a few new/changed enemy encounters, a small, Pain mode only area to see, and a Pain mode only post-ending scene (about the same length and level of importance as the one you get for using no joy on a normal runthrough).