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Disintegration has good numbers, but is extremely punishing to use and has some rng in its targeting. Burgeoning is also really rng but is pretty amazing combined with its low cooldown.
Pyrokinesis never will do enough damage, but cryokinesis atleast has a chance to freeze them to easily stop them from splitting.
If none of that is helpful, you can use normality. Easiest way is to aquire an ontological anchor early on from putus or quest rewards, then just power it on and put it on the ground. Lead twinning/tripling lamprey over and it makes things much simpler.
Electrical generation is pretty good too and can be combo'd from food to ignore the "CD", but does not have the radius of disintegration, though the chaining might be even better.
It is a 7x7 square, not radius 7 (which would be pretty massive).
Ah, right... I tend to forget that some abilities work in a square instead of a more logical circle.
7 radius would be pretty huge, but then again, it's an ability that stuns you for three full rounds after you use it. Thinking back, the disappointing range is probably why I stopped ever taking this mutation.
thinking both of what to look out for when buying mutations and potential answers to this problem in future builds - stuff that can clear out large blocks of enemies, ideally simultaneously and at range but allowances can be made
The game generally doesn't have many great reusable AoEs.
Mark III High-Explosive grenades are pretty solid, and they're not expensive to craft. Like pretty much all grenades it only requires Tinker I to craft.
The lampreys have the special of the cloning, but AOE is not the only way to go about that as pointed out earlier with cryokinesis. Almost any kind of CC and also normality will keep them from cloning and that is usually more accessible than AOEs that deal enough damage to kill both of them in the same turn, unless you prepare them down to low HP before you use it.
The game really does have much AOE spam outside of grenades and some weapons (e.g. arc-winders, eigen-weapons) that can just kill lots of not-that-weak enemies. For mutants specifically there is also acid gas generation, but that might not be the thing you are asking for. The damage can ramp up petty high and it forms a protective layer around you though. Personally I just kill the lampreys with some freezing or the carbine gotten from the Golgotha quest, since that has multishot.
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That said you can make AOE spam with food triggers, but for that you need to do some combo stuff that might be more accessible when you've experimented with it a bit. You can get multiple AOE effects from a single trigger try (like an attack that causes 5 instances of electrical damage) and can nuke targets with that.. but afterwards the enemies get a turns for each of those actions you did. It can help a lot, but also kill you if something survives the nuke and gets multiple free attacks on you. If those actions were multiple cryo-/pyrokinesis casts though and you've shielded yourself with the AOE, that can be less of an issue. Lampreys are too dumb to get CC'd by fire though.