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But as far as leveling goes I usually hit up a ruin or two to get myself some decent experience and gear before heading in. As of a few patches ago I never have to worry about having enough to trade for, or simply find Fulrite Plate amongst other decent Ego Boosting gear/weapons.
If you're looking for an in-depth guide to Golgotha, I'd suggest the wiki page for further information:
http://cavesofqud.wikia.com/wiki/Golgotha
Edit: Forgot to mention I usually go in as a pure esper, stat dumping into Ego for more rapid levels in my mutations.
As to what is best for clearing Golgotha: Grenades! Lots of Grenades! Also, regardless of what build you use, try to get a Carabine, Chain Pistol or some other multi-shot ranged weapon - those really help with crowd control, mowing down weaker creatures with ease.
Also, remember you don't have to fight the boss down there - don't get greedy, grab the droid and recall back up if you don't feel like facing him yet ;) And if you do, my tactic is - Freeze Grenades! Lots of Freeze Grenades!
1. Avoid the vents on the conveyor belt. They do massive damage that ignores all defenses. Most deaths to Golgotha are probably a result of getting hit by them.
2. Carry lots of healing injectors and use them as soon as you take serious damage. Golgotha is dangerous, and it's entirely worth burning all your injectors to get through it.
3. Go as quickly as possible. Golgotha is full of really dangerous stuff, so you want to spend as little time there as possible.
4. Avoid the boss. He's really really nasty.
5. Don't walk on the ooze if you can possibly avoid it; it slows you down, and monsters will pop out of it and attack you.
Teleport + Clairvoyance is a good combo for it. I would suggest Force Wall as well, but that should work. Just be careful about your teleportation's cooldown -- use Clairvoyance to find safe spots and teleport to them as you make your way down. With this build you can mostly avoid the conveyor belt (usually you're forced to dash down it while avoiding the vents.)
If you have any, bringing poison resistance and elemental resistances will help against the vents and some of the special attacks, but it isn't strictly necessary.
Also, once you're in the bottom level and have the broken waydroid, your goal is in the top middle. You should head there first as soon as you reach the bottom, since you might find the waydroid on the way and it gives you a relatively safe spot to move out of. (Just don't use the elevator until you have the waydroid -- it's one-way.)
You want other mutations in the late game for things with very very high AV or HP, but otherwise, Light Manipulation is pretty good. It's 100% accurate, and its high PV later on will let it do very heavy damage to poorly-armored opponents, while its large number of shots makes it easy to use it to take out anything that isn't ridiculously tough and which doesn't have to be killed instantly. That lets you save the really big guns like Sunder Mind for more dangerous opponents.
And the other ones have their own disadvantages. Sunder Mind doesn't work on mindless things (a category that includes, incidentally, the boss of Golgotha. I'm not 100% sure why he's immune, but he is.) It also doesn't tend to work on late-game enemy espers, since they have mental mirror. Pyrokinesis and Cryokinesis tend to destroy loot. And all three of those have somewhat longer cooldowns, so if you rely exclusively on them you might get stuck without an option. Light Manipulation doesn't hit as hard, but it's much more reliable.
(Light Manipulation also works well with Menacing Stare and Intimidate, which can buy you time to unload multiple hits on even more dangerous enemies.)
Incidentally, I feel the best ranged mutations in the game are the flaming / freezing hands ones, but of course they're not mental mutations. Very short cooldown, very high damage, hits every enemy in a line to your target while bypassing most defenses. But obviously those are for different types of characters.
Actually, while I'm being a pest, do recoilers still have to be recharged with cells or has that changed recently?
Recoilers still need to be charged with an energy cell for them to work.
(Having solar cells is nice. A fully-charged solar cell can power one recoiler use. Alternatively, if you have basic tinkering, you can recharge your cells yourself... or you can pay a bit of water to have a merchant do it.)
Recoiler can be a bit problematic to use since it is hard to find places with no enemies around in the vents. Worse still if you happen to go down one with the crabs. It still might be the best decision to spring down all the way than to stay there.
I searched every nook and cranny of the whole Tunnel, and there was no Sphere. I've never found one in there.