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Esper is just another playstyle and allows you to buy a guaranteed new mental mutation every 4 levels, making sure every one of your abilities reaches godlike levels due to ego focus. You will also get glimmer up really high quickly, which has both its down- and upsides. If your plan is to mainly put mutation points into mutations to level them (instead of constantly getting new ones) and focus on something else than pure ego, Esper is probably not worth it.
Really depends on your plan and your tolerance for glimmer fights.
But you certainly can get crushed by RNG some games as a non-Esper, while as an Esper you can start with e.g. Burgeoning, Force Wall, Teleport Other, Clairvoyance, Mental Mirror, and Blinking Tic and know that you'll have already bought all the 2 and a chunk of the 3 cost mental mutations and you can count on usually having pretty good choices from RNG on account.
Every 4 levels you can get another kill button though and everything just gets stronger and stronger, while you get more and more skills with less and less cooldown. A lot of people probably want to start with really strong mutations instead of just getting the most and cheapest and Esper makes sure they get almost all of them.
Espers are definitely playable, but their early and late game have some very different elements to face. I totally agree that the higher point mental defects are much more impacting than the physical ones. Just looking at them makes me want to pick none of them, though evil twin is something one can game around.
(Also if you pre-spawn Burgeoning until you get 5-6 feral lah you can wipe out a couple equimax herds and get your first couple random mutations if the grab bag of cheap stuff doesn't feel good.)