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On the plus side if you defeat them there's a chance you can eat their minds and gain a point of Ego.
Start with 18 toughness, 24 willpower, 18 ego, Pyrokinesis, Cyrokinesis, Clairvoyance, a defensive mutation of your choice, and pick either Greybeard or Pilgrim.
Put all extra stat points you gain from leveling into willpower up to 32 for an 80% cooldown reduction, use your mutation points to power up your core mutations rather than buying new ones.
You will eventually start encountering psychic assassins but much later and by that point you'll be out scaling them in power.
Oh wow, I put very little into Willpower so that's news to me. Thanks for the advice!
Ironically, esper builds prefer keeping ego as low as possible at chargen. It's easy enough to boost ego later with two faced knollworm helmets and the dismembered faces of your foes.
Sounds fun, I'll try it sometime. That said, I think physical mutation Electrical Generation or Freezing Hands is way stronger than Pyro/Cryo, especially when you throw RA's into the mix. You ALWAYS want at least one physical mutation at chargen just for the RA's.
Right now my favorite ego abilities are the good old Precognition and Clairvoyance. There are lots of ways to get high damage - skills, stats, weapons, guns, tinkering, grenades - but there is only one way for mutants to safely drink Neutron Flux, and only one way for mutants to detect enemies that can inflict instant kills before it's too late.
Apostle, 18 in all stats 14 in ego, optionally dump ego all the way to 10 to bump wisdom, toughness, or intelligence higher. Precog, Clairvoyances, Regeneration, Unstable Genome x2. The first three abilities are completely vital in the late game, unstable genome keeps the build from getting boring.
I get to level 21 or so the hard way, then I give in to the Proselytize+merchant cheese. I figure if I can get to midgame without cheese, I don't have to feel guilty about rewarding myself with free stuff. By midgame earning money is mostly a formality, anyway.