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esper: same but only mental mutations.
genome: 33% chance per level to be able to pick 1 of 3 random mutations, repeatable.
you cant pick esper and chimera together, you can pick genome with either or none.
More specifically: you get a mutation point every level. You can spend 4 points to get a new mutation, this lets you pick from 3 random mutations out of all the ones your character is allowed to have. Chimera or Esper let you limit that pool of available mutations to ones that fit your build better, raising your chances of getting choices that are actually useful.
So if you initially pick mental mutations, and focus on raising wisdom/ego so you can play as a sort of ranged caster, you want to take Esper so that your random mutation choices aren't full of physical mutations that don't work with your build. Vice versa for physical mutants raising strength/agility and taking Chimera.
You could take neither, which frees you to start with some OP combination of mental and physical mutations (some of them DO work well together, it's just that most don't). But then you raise your risk of getting some weird random mutation choices that just don't work with your build as you level up.
Unstable Genome is unrelated, it lets any mutant spend 3 points for an extra random mutation after a few levels. It's like a gamble, hoping to get a good mutation that costs more than 3.
There are exceptions, yeah, but overall most physical mutations are bad.
disagree, i'm playing a duel-wielder with axes with adrenal control and an extra pair of arms, making him incredibly powerful.
(The other issue is that physical mutants learn fewer new mutations in general because they need to spend their mutation points leveling up the mutations they already have, which makes the Chimera genotype even less useful.)
I mean, I'll bet your axe-guy wasn't actually a Chimera... was he? It'd just be a waste of a point.
(Regeneration in particular I still feel is a trap. Even at max level the health regen is far too low to help you against the most dangerous enemies, and while regenerating limbs is nice, it's not worth devoting an entire mutation to.)
If I hadn't chosen chimera, my random mutation rolls would've been cluttered with mental mutations that wouldn't provide much of an advantage for a physical attacker. For a single mutation point, chimera is much more beneficial then something like kindle or night vision.