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Appearently, you're right. Getting a cursed gun during a blessed run does increase your curse permanently for that run.
Source: http://enterthegungeon.gamepedia.com/Sorceress
Edit: No idea, how to remove that curse for that run, unless you stumble upon a Cleanse-Shrine or roll "Cleansed" at a Dice-Shrine.
However if that is the case, the Cleanse shrine that removes curse probably resets it.
That how I met Lord of the Jammed for the first time.