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I think they're the easiest floor 1 boss. They have the smallest health pool and mostly predictable pattern (easily the most predictable once you kill one of them.)
Keys to the fight are kill the spawns the moment they show up, and shoot whichever twin is closest to you. Try to focus down one of them first, because the fight is super easy once one of them dies. There's not much point in trying to whittle both of them down because whoever is left regains a ton of HP. The reason you even take pot shots at the other guy is it keeps them from getting too close.
So, git gud.
https://www.youtube.com/watch?v=2JwDH88WZzk&list=PLiEqllSQZtTpKEQykLDM38KiK3G0-m3oQ
The hardest floor 1 boss to flawless is Gatling Gull.
Twin Triggers aren't too strong imho, focus one so that you'll have to deal with only one of them, even if it's enraged.
Twins and gatling gull are easy.
I think by the time Ch 3 comes around. If you didn't get a good set of weapons/items then it's game over. Does anyone think it's doable without weapons/items? I'm sure it has to be for the shortcut unlocks.
EDIT: I suppose you could grind the Oubliette to get the Shells/keys needed. An extra floor...
EDIT2: I found my first ever game and I died to the TT too, lol. I think it's impossible to know they regenerate without spoilers the first time. So, I wiped (also, no weapon):
https://www.youtube.com/watch?v=x-X-MeHw3uw&list=PLJqoU7EItaZcIvAzXK_s--O5PRnZDidZf&index=1
You usually have a weapon by then. I'm not even entirely sure you can get to floor 2 boss without having passed at least 1 weapon. Don't blow all the ammo from it on room fights if it's the only one you have.
Of course there are weapons actually worse than the basic gun, but there really aren't many of those.