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I had Hexagun + Muscle Relxant + Omega Bullets once....
That was already stupid strong. I think that's like 9x damage per shot.
Killed nearly everthing in one shot except for a few jammed enemies.
Gear is also good for most weapons. Got it once with megahand - although it is hard to catch reloading time, if you do, charged shots are one-shot killing everyone.
Bee Hive + electrified bullets.
Everyone in the room is in love with me and fighting each other.
Barely seen Alpha or Omega since though :(
If you can find all three, its a free trip to the forth chanmber, really really easy to get there with this, and they can all be found on the first chamber,
(Is there a such thing as 3 item synergies?)
Essentially infinite ammo if you know what you're doing.
also, Heck Blaster + Chance Bullets + Combined Rifle
Swap the Combined Rifle over to it's energy blast, then fire away with the Heck Blaster. You'll fire off so many of the energy blasts it's insane.