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Alternate your punches. With each opportunity to hit him, you can do so 6 times by going left-right-left-right-left-right instead of the 3 that you get just going left-left-left.
Whenever he flashes yellow, you can punch him to interrupt whatever he's doing and get a super. This requires experience with his attacks to know when it's coming for each, since you can't generally react fast enough to get them without knowing they're coming, but watching videos can help too so you have a general idea. Getting hit makes you lose your supers.
Finishing off one of his health bars with a super guarantees an extra key drop, so you can get up to 5 by finishing each health bar with a super (you can get a 6th by finishing each health bar with triple-charged supers, but I really wouldn't recommend trying to do that until you have way more experience with the fight). Note that he can't block supers, so you don't have to work them into a combo if you get him low enough.
When he goes to heal, you can punch the hand the cheese is in right before he eats it to stop him and get a super. He will hit you if you miss the timing, but that hit is odd in that it only does a very tiny amount of damage and doesn't make you lose your supers.
I know it's not optimal, but personally I don't go for supers on his first health bar except for when he does his pose. They're easier to get on the second and third bars, IMO, because you can interrupt his punch-punch-punch-uppercut combo on the second or third punch without having to react quickly (just timing your punch precisely). His windup punch and heal moves also give you opportunities to get supers with just good timing rather than fast reflexes, though the windup punch is very dangerous if you screw up the timing.
Check out this post for a good video and a few more tips.
https://www.reddit.com/r/EnterTheGungeon/comments/915lxw/spoilers_full_secret_boss_fight/
Punch Out phase starts 2 minutes into the video.
Also, yes, that and the mystery egg are the only ways to face the advanced dragun. However, as noted above, you don't have to completely beat him to get a second key, just deplete one of his health bars with a super. Also, you can kinda cheese the locks (particularly the second one); you can drop your items at the gate and then use explosive weapons or blanks to push them through it to feed the baby dragun. I could see that getting fixed, though. Bloodstained Scarf will also let you teleport past them, but obviously that's not reliable.