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Then combine "Shotgun Full of Love" with the "Pink Guon Stone" and you have an amazing synergy which I was lucky to get early on throughout the run.
I love Makeshift Cannon. It's a Star Trek reference, for one thing. And for another, it one-shots anything in the game except Rat, Dragun, and Lich. Duct Tape it to something with more ammo and you've got a winning run right there.
Casey is incredibly fun to use. So is the Boxing Glove, although it is significantly worse than Casey in terms of min/max.
I really dig Megahand too, for being a Mega Man reference. Helps that it's also one of the best room clearers in the game. Now that they added synergies that give you all the Mega Man 2 boss weapons as well, that's just icing on the cake.
The synergy is not very good (Cactus + Starpew, it basically makes the cactus a shotgun with very high spread and excellent fire rate), but with the Flak Bullet, it's OP. It floods the entire room with projectiles, just wiggle it around, from left to right, and the enemies will be dead before you notice it.
But my favorite gun is definitely the Mahoguny, good damages, good fire rate, and AoE. Perfect.
As for a fun/stupid combo: Particulator and easy reload bullets. No synergy but still hilarious when you can fire it constantly and clear out rooms with your eyes closed. Pretty decent boss killer as well.