What is the best class combinations?

[Loli]

I'm new to the game and I can't find any guides so I thought I could get some help here

[Red]

Best class is usually a "relative" thing depending on the area and what you will encounter. Assassin/Warrior is usually regarded as highest constant DPS, though Mesmers have very high armor ignoring damage which is ideal for Hard Mode in the game. Everything has it's pros and cons, though some have a better "one size fits all" approach than others. Find what you like to play, and PvXwiki is bound to have a current (ish) meta build for it that is good for certain areas.

[Loli]

Ok thanks

[Red]

I should clarify, that is the Assassin with Warrior as a secondary, not Assassin & Warrior classes. If you have any more indepth questions feel free to add me and ask

[c0Zm1c]

The Wiki[wiki.guildwars.com] has guides on each profession, but it is also good to experiment.