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I wouldn't put blue into a main gem, better make two gems, one for killing and one for slowing.
And white/black specials cannot be amplified, so it would be useless to put those gems into the amplifiers.
I meant black, not blue. My bad!
In late game your "killgems" will be yellow/white and/or yellow/black with just a touch of red. That red won't need amping, and white and black specials can't be amped, so your amplifiers will want yellow only.
You might also use purple and cyan in traps... they're usually good enough on their own to not need amping.
If you run a mana farm you MIGHT want to augment it with orange amps.... but I wouldn't recommend it.
Care to elaborate on this?
Sure.
One tactic players use is a "mana farm" - a large collection of traps or towers slotted with orange mana leech gems. The purpose is not to stack up damage, but to leech up large quantities of mana quickly to pay for upgrades for your other gems.
Adding an amplifier with an orange gem in it would increase the leeching effect of any nearby gems, but I'm pretty sure just adding another orange-gem-trap would be cheaper and give better returns.
An extra gem makes lag worse though, while the amplifier(s) don't.
Also, according to my math, adding amplifiers to a managem always makes it more cost-efficient than leaving it amp-less, provided you use a reasonable amp-gem cost proportion.