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The basic setup for lab should be somewhat of a 1:3 ratio of upgrade 5 and 6 for the start at least.
You can put a few point in upgrade 4 if you want to push supernovas and respec back to 1:3 ratio when you are in dialiation again.
At the start you should try to prioritise dilation upgrades 1 and 2 and exit dialation often to speed up the DP gain. I haven't figured out the math behind the perfect ratios of the upgrades yet, but from the general feel upgrades 3 and 4 are the strongest for pushing, upgrade 5 is kinda meh but shouldn't be overlooked and upgrade 6 is very strong again.
After you've gotten a few dialation upgrades, your rotation should be:
Deep dialation run -> Push for supernova/lab upgrades -> deep dialation run and so forth
Additionally it's very beneficial to pump up the eternities count. They give progressively less bonuses as it seems like a logarithmic curve, but I would definitely advice to get them up to around 250k-ish so let it run over night once or twice.
Lastly here are some (estimated) Breakpoints for when I attempted certain challenges:
Challenge 9 #2: supernova 46
Challenge 10 #1 Supernova 48/49 (or 1e10000 dialation score)
Challenge 9 #3: Supernova 56 (also make sure to respec your lab setup and pump everything into the 6th upgrade)
Challenge 10 #2: I attempted it around 1e70000 dialation score, but you definitely can do this way earlier as I completed the challenge in like a minute, so I guess somewhere around dialation score 1e50000.
Also make sure to disable auto ascenscion for red here and ascend manually once you have enough score to pump it up once or twice, or else it will slow down your progression.
This should take you around 7-8 days to complete (from personal experience :P )
Hope that helps
EDIT: forgot to add: After each challenge 9 you should adjust your lab ratios, I don't remember what I did but with each upgrade I went harder on upgrade 5 instead of 6. I advice to just play around and test it out (try old ratio for 1 min and note score result -> try new ratio for 1 min and see if it improves)
Thanks for your reply, I will apply your advices.