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1) Spend them to open chests and doors
2) About 30% into the game, you meet a blacksmith that can break the runes for you to generate powerups for your weapon.
It's after the 4th boss I think that you progress to the area where you meet the smith.
Care to elaborate on how i use them on doors and chests?
When you use the Blacksmith to open your runes always spend the maximum 1k xp on the big runes. You get maybe 8 all game and you'll want them to be Flawless. With the small runes its upto you if you want to spend xp opening them.