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Edit: i did it.
Know I've done it with ventrue, brujah, and tremere.
Blood Buff. The extra dex and str will help. Also, all your other disciplines will help too (Celerity, Presence, Potence, Fortitude)
Don't forget about blood packs when your health and blood are both low.
If you have Obfuscate, you can jump up and down behind a painting and go hidden. Then sneak up behind him and you can stealth kill him.
If you have any trance-like Discipline, such as the Dementation which makes them laugh (I think Dominate and Animalism have similar powers), you can cast it on him, walk up behind him, and stealth kill him.
If you have Thaum, you can spam attack on him while casting the second level to incapacitate him. I think it takes about two casts to finish him off.
Now how quickly the guardian lashes back depends on your combined celerity/presence levels, so adjust accordingly. Celerity makes you faster and presence makes the opponent attack less often. These combine to what I think is the most potent combat discipline combo in the game. (ironic that it is Toreador, neh?)
ps. guardian is definitely not a 'walk in the park' when you are just starting the game, but thankfully you can do many other quests first and get xp. It will be a long time before you run into something as dangerous.