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1) Replacement: Just buy a cheap rune from a store (go to Last Hope or the mage city), use it and override the offending infusion.
2) Become Undead: Becoming undead will remove all infusions from your body.
You can replace an Infusion with a Rune, just as Anhedonia said:
Go to a Rune store in Last Hope or Angolwen and buy a Rune. Use the Rune via inventory and replace one of your Infusions with it. In order for Runeskin to work properly you need to not have a single Infusion. So if you have, say 3 Infusions(Wild, Heal, Movement)... you'll need to use 3 Runes to replace all of them.
Replacing worked for me. I initially had Movement and Regen Infusions when I grabbed Runeskin. I had to replace them with a Shatter Afflictions and Shield Rune. So barring some bug, it should work for you. Otherwise, becoming Undead should solve it.
Inscription Slots: You start with 3, you can buy up to 2 more with category points. Ogres can get a sixth slot, but you need to get a racial talent to level 5 to buy it.
Different things can be put into them: Infusions, Runes, Injectors, Steam Generators, Taints (a type of rune)
Most characters will only ever find Infusions and Runes, so we can ignore the others.
Infusions: These are nature gifts, made from fungus and mosses. If you have any of these in a slot then it will disable your Runeskin talent. Historically these were better than runes, but have since been more or less equalized.
Runes: These are magical tattoos. Each rune on your body will increase the potency of Runeskin. Using these are spells, as such you can't use them if you are silenced.
Most characters start with 3 infusions already equipped. Just buy 3 cheap runes and replace them all.