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P.S. The old school (Pre-EE) answer would have been to summon 5 skeleton warriors who used to be immune to the Mind-Flayer brain drain. Sadly in EE Skele's get demolished by flayers in 6 seconds flat.
2 - use them on the other machine to create a enthralling collar;
3 - go back in the brine potion workshop room and enslave the mind flayer that respawn in that spot with the enthralling collar;
4 - make that mind flayer walk near the locked door in the room on the upper part of the map.
The door will blast open, but be aware that the mind flayer will go hostile as soon as the door open.
Alternatively, use slayer form and force attack (bash) the door. Will also open it, but it’s a waste.
The enemies at the upper room are optional, but afaik one of them drop an artifact piece to reforging later with cromwell.
I know the old BG2 didn’t have the immunity flag on skeletons, but EE version they’re immune to intelligence drain, no? Animate dead is a good option, since it will endure for other fights.
Cloud Kill is like bug spray on them!
Open the door, drop a cloudkill into the room (wand of Cloudkill is great for this because it's so fast!) quickly close door. Laugh manically as all Umberhulks in the room drop dead.
Cernd and Korgan are especially effective because hit like trucks and can really take a beating; Minsc hits hard too but is more fragile. Of course a tank main character could do the job as well.
If have freedom (item or spell) may also use web or other similar effects to pick the targets one by one; in such case may avoid cloudkill.
Last, any high STR character with a good sling can lay waste upon anything in a short time: if opt for this approach mind that some spells/abilities cast by the flayers and umber hulks have an area of effect so either protect all the party or send them away from the slinger
The problem was I think that my companions got drained by mind flayer, despite the brine potion. The strategy was summoning monsters constantly throughout the battle. While I attacked with bow and crossbow constantly.
Still I do not know how to protect my party members from draining. The brine potion did not seem to work. Or there is another protection method. Chaotic command at least not.
The potion and chaotic command reduce the risk by preventing being knocked out but do not stop the drain itself.
Actually the best way is to squish quickly the flayers: 3rd level spell haste is extremely helpful at that (it also gives a bonus to AC).
BTW Timestop+polymorph self into a mindflayer is a "classic" to quickly dispatch hard foes
Noteworthy things near that room was the Staff of Command (no saving throw) behind a secret door beside the door to the Elder Brain and an improved ring of fire resistance from the dwarvish fighter in a room south of that area. It's not a bad idea to keep any extra Control Collars you made, as far as I can remember (I haven't reconfirmed in BG2:EE) they can control anything without saving throws and bypassing magic resistance.