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I usually go Megasatan Chest > Megasatan dark room (hope for void) > Mother > ascent (get tainted character) > Boss rush > hush > delirium > ultra greed
Chances are a void portal and a mama mega will pop up on one of those runs to open up void or hush on a "minmaxxy" run but chasing the timer also can be fun
On the tainted characters and most characters I'm currently waiting to do their unlocks because there's a lot that are really good and some that are just bad. Out of the reverse tarot cards. Most of the ones I have are really good. And getting unlocks that help with manipulating secret room and angel room pools are also really helpful. Getting an R key can add multiple completion marks and mama mega can really save a really good run going nowhere useful
Other suggestions ?
Kill the Heart 11 times in total, then the Cathedral and Sheol 5 times each. Even better if you kill Hush 3 times on the way. After your first Chest / Dark Room win, unlock Dad's Key.
Once you've done all that, you'll have access to most things.
Well, I guess I'll do that then !
I kinda thought I could already try and do some time saving because I have a hard time with understanding why I should do two runs to kill MH then Satan when I can do it in half the time.
But yeah, knowing I'm still learning, I guess I should focus first on learning to avoid taking damages and stuff.
Thanks for the advices !
So if you kill Mom's Heart and a Devil room opens, just go to Sheol, you'll speed up the "kill Satan 5 times" unlock. The Heart unlock of that run is already unlocked, no need to end the run now.
(The same logic applies to every boss in the game.)