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Once your Lemon Party pill is gone, it pretty much plays out as a vanilla-run Isaac to Mom, which i wouldn't find difficult, but to make it easier, you'll be able to use Lemon Mishap once per floor.
If you are having troubles, my advice would be to stock up on money, go for shops and if it's something like the Champion Belt, i'd recommend that.
If that fails then just use the lemon misshap ability in each room to mop up most of the enemies and don't get hurt while focusing on getting some good tears since lemon misshap is a great spacebar item already.
Got pretty strong and tiny on my lemon run:
http://steamcommunity.com/sharedfiles/filedetails/?id=356505344
You could find a really good item with two or three charges?