Quickest you've gotten Guppy?

[Redronn]

I just got Guppy before killing Mom's foot, and it's the second time for me, so I'm going to have fun with this run. :D I also have quad shot and polyphemus.

Here's the seed if anyone wants it: 9S8KQJGV

[Bhris Benoit]

Quickest I have ever gotten Guppy was third floor thanks to Guppys Tail and Left Hand.

[Kinne]

I got 2 guppy items in the first curse room. But it was one of those runs where the game had no intention of giving you even a sliver of a chance to win. So it ended shortly after.

[Doniazade]

First floor devil room via curse room. Pretty much guaranteed win from that point since Guppy is incredibly good.

[DeathFed]

i got guppy transformation on the 2 floor devil room 3 guppy items asap but then i ♥♥♥♥♥♥ the run up by taking dr fetus from boss rush at the same time i had mom's eye and mr mega

[bullex]

First floor - Joker card - 3 red chests with Guppy items

[Redronn]

Some of the things I now have before reaching Mom's Heart: Guppy, Quad shot, Polyphemus, 3 pretty flies, Dark bum, Tammy's head, Gimpy, Goat head, Cancer, Infamy, 9 lives, a ton of damage.

Going rather well. :) If I die now, I'll admit I'm the worst Isaac player alive.

Something random (huehue): The game apparently really wants me to kill myself, because I've gotten Bob's brain 4 times from golden chests, 2 times in a row just now, in adjacent rooms.

[Santi]

I got two guppy items in those three red chest in those trap rooms, following by another guppy item in a devil room. Lovely.

[Shayla]

1st floor curse room 3 chest. 1st red chest was the head, 2nd red chest was the tail. Rerolled the head and got the collar.

[Radioactive Man]

Same as above honestly. Plus destroyed the game on that run.